In 2019, the father-of-two, 46, was on an episode of Hot Ones when his friendship with the mogul, 54, was brought up.
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"I've got a lot I can't tell," Kutcher confessed before taking a pause. "I can't tell that one either."
The stars became friends when they were both starring on MTV shows, as while the Hollywood hunk hosted Punk'd, Combs ran Making the Band.
It's unclear if the two are still pals, but an insider told a news outlet Kutcher and wife Mila Kunis are worried he could be subpoenaed. Whether he is or not, the source noted, "There is no way in h--- Ashton or Mila will be showing any sort of public support for Diddy right now."
The couple recently came under fire after it was revealed that they wrote character letters for costar Danny Masterson, who is currently in prison on rape charges.
After the backlash, they issued an apology and stated they "support victims."
"The letters were not written to question the legitimacy of the judicial system or the validity of the jury's ruling," the couple explained. "They were intended for the judge to read and not to undermine the testimony of the victims or retraumatize them in any way. We would never want to do that. And we're sorry if that has taken place."